MONOCLONAL ANTI-GALECTIN 8

Code: G5671-100UL D2-231

Application

Monoclonal Anti-galectin-8 antibody produced in mouse has been used for: immunoblotting immunocytochemistry enzyme linked immunosorbent assay (ELISA)


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€498.00 100UL
€612.54 inc. VAT

Application

Monoclonal Anti-galectin-8 antibody produced in mouse has been used for: immunoblotting immunocytochemistry enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions

Galectins belong to a family of carbohydrate-binding proteins. These proteins share similarities in the carbohydrate recognition domain (CRD) and in their specificity for N-Acetyllactosamine-enriched glycoconjugates. The binding of galectins to saccharides modulates cell proliferation, cell death and cell migration, which are involved in cancer initiation and progression. Galectin 8 is a secreted protein that requires both of its CRDs to be active to modulate cell adhesion. It forms a complex with integrins and triggers integrin-mediated signaling cascades. On the contrary, excessive amounts of this protein negatively regulate cell adhesion by interacting with integrins. These signals assist in identifying regions available for cell adhesion and migration. It may be involved in neoplastic transformation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Galectin 8 (mouse IgM isotype) is derived from the hybridoma VA-11.25 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant rat galectin 8.Galectins belong to a family of carbohydrate-binding proteins. Within this family of proteins, galectin 8 is unique, as it exists in many forms encoded by the same gene.

Galectins specifically bind to β-galactosides. 15 mammalian galectins have been identified so far. Galectin 8 contains two CRDs connected by a short linker peptide.

Immunogen

recombinant rat galectin 8.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Specificity

The antibody has low cross-reactivity with galectin 3 and galectin 9.

antibody formpurified from hybridoma cell culture
antibody product typeprimary antibodies
biological sourcemouse
cloneVA-11.25, monoclonal
concentration~1.0 mg/mL
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... LGALS8(3964)mouse ... Lgals8(56048)rat ... Lgals8(116641)
isotypeIgM
mol wtantigen ~34 kDa
Quality Level200
shipped indry ice
species reactivityrat, human, mouse
storage temp.−20°C
technique(s)indirect ELISA: suitable, immunocytochemistry: suitable, western blot: 1-2 µg/mL using rat galectin 8 recombinant protein
UniProt accession no.O00214
This product has met the following criteria to qualify for the following awards:



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